2ayo: Difference between revisions

Revision as of 13:27, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2ayo.png

Template:STRUCTURE 2ayo

Structure of USP14 bound to ubquitin aldehydeStructure of USP14 bound to ubquitin aldehyde

Template:ABSTRACT PUBMED 16211010

About this StructureAbout this Structure

2AYO is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14., Hu M, Li P, Song L, Jeffrey PD, Chenova TA, Wilkinson KD, Cohen RE, Shi Y, EMBO J. 2005 Nov 2;24(21):3747-56. Epub 2005 Oct 6. PMID:16211010

Page seeded by OCA on Mon Jul 28 13:27:57 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Structure of USP14 bound to ubquitin aldehyde'''
+===Structure of USP14 bound to ubquitin aldehyde===
-==Overview==
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-The ubiquitin-specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. Mammalian USP14 (Ubp6 in yeast) is unique among known UBP enzymes in that it is activated catalytically upon specific association with the 26S proteasome. Here, we report the crystal structures of the 45-kDa catalytic domain of USP14 in isolation and in a complex with ubiquitin aldehyde, which reveal distinct structural features. In the absence of ubiquitin binding, the catalytic cleft leading to the active site of USP14 is blocked by two surface loops. Binding by ubiquitin induces a significant conformational change that translocates the two surface loops thereby allowing access of the ubiquitin C-terminus to the active site. These structural observations, in conjunction with biochemical characterization, identify important regulatory mechanisms for USP14.
+The line below this paragraph, {{ABSTRACT_PUBMED_16211010}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_16211010}}
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 [[Category: Proteasome]]
 [[Category: Usp14]]
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