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| {{STRUCTURE_2f6m| PDB=2f6m | SCENE= }} | | {{STRUCTURE_2f6m| PDB=2f6m | SCENE= }} |
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| '''Structure of a Vps23-C:Vps28-N subcomplex'''
| | ===Structure of a Vps23-C:Vps28-N subcomplex=== |
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| ==Overview==
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| The endosomal sorting complex required for transport (ESCRT) complexes are central to receptor downregulation, lysosome biogenesis, and budding of HIV. The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37 proteins, and its assembly is directed by the C-terminal steadiness box of Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37. The crystal structures of a Vps23:Vps28 core subcomplex and the Vps23:Vps28:Vps37 core were solved at 2.1 and 2.8 A resolution. Each subunit contains a structurally similar pair of helices that form the core. The N-terminal domain of Vps28 has a hydrophobic binding site on its surface that is conformationally dynamic. The C-terminal domain of Vps28 binds the ESCRT-II complex. The structure shows how ESCRT-I is assembled by a compact core from which the Vps23 UEV domain, the Vps28 C domain, and other domains project to bind their partners. | | The line below this paragraph, {{ABSTRACT_PUBMED_16615894}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16615894 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16615894}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Vps23]] | | [[Category: Vps23]] |
| [[Category: Vps28]] | | [[Category: Vps28]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:31:33 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:25:41 2008'' |