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| [[Image:1ymt.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1ymt| PDB=1ymt | SCENE= }} | | {{STRUCTURE_1ymt| PDB=1ymt | SCENE= }} |
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| '''Mouse SF-1 LBD'''
| | ===Mouse SF-1 LBD=== |
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| ==Overview==
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| Vertebrate members of the nuclear receptor NR5A subfamily, which includes steroidogenic factor 1 (SF-1) and liver receptor homolog 1 (LRH-1), regulate crucial aspects of development, endocrine homeostasis, and metabolism. Mouse LRH-1 is believed to be a ligand-independent transcription factor with a large and empty hydrophobic pocket. Here we present structural and biochemical data for three other NR5A members-mouse and human SF-1 and human LRH-1-which reveal that these receptors bind phosphatidyl inositol second messengers and that ligand binding is required for maximal activity. Evolutionary analysis of structure-function relationships across the SF-1/LRH-1 subfamily indicates that ligand binding is the ancestral state of NR5A receptors and was uniquely diminished or altered in the rodent LRH-1 lineage. We propose that phospholipids regulate gene expression by directly binding to NR5A nuclear receptors.
| | The line below this paragraph, {{ABSTRACT_PUBMED_15707893}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15707893 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15707893}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Phosphatidyl glycerol]] | | [[Category: Phosphatidyl glycerol]] |
| [[Category: Sf-1]] | | [[Category: Sf-1]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:31:17 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:09:25 2008'' |