2fom: Difference between revisions

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[[Image:2fom.gif|left|200px]]
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{{STRUCTURE_2fom|  PDB=2fom  |  SCENE=  }}  
{{STRUCTURE_2fom|  PDB=2fom  |  SCENE=  }}  


'''Dengue Virus NS2B/NS3 Protease'''
===Dengue Virus NS2B/NS3 Protease===




==Overview==
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The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.
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{{ABSTRACT_PUBMED_16532006}}


==About this Structure==
==About this Structure==
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[[Category: Ns2b cofactor]]
[[Category: Ns2b cofactor]]
[[Category: Ns3 protease]]
[[Category: Ns3 protease]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:08:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:54:29 2008''

Revision as of 12:54, 28 July 2008

File:2fom.png

Template:STRUCTURE 2fom

Dengue Virus NS2B/NS3 ProteaseDengue Virus NS2B/NS3 Protease

Template:ABSTRACT PUBMED 16532006

About this StructureAbout this Structure

2FOM is a Protein complex structure of sequences from Dengue virus 2. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus., Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U, Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12. PMID:16532006

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