1oc7: Difference between revisions

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-[[Image:1oc7.jpg|left|200px]]
+{{Seed}}
+[[Image:1oc7.png|left|200px]]
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 {{STRUCTURE_1oc7|  PDB=1oc7  |  SCENE=  }}
-'''D405N MUTANT OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH METHYL-TETRATHIO-ALPHA-D-CELLOPENTOSIDE AT 1.1 ANGSTROM RESOLUTION'''
+===D405N MUTANT OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH METHYL-TETRATHIO-ALPHA-D-CELLOPENTOSIDE AT 1.1 ANGSTROM RESOLUTION===
-==Overview==
+<!--
-The enzymatic digestion of cellulose entails intimate involvement of cellobiohydrolases, whose characteristic active-center tunnel contributes to a processive degradation of the polysaccharide. The cellobiohydrolase Cel6A displays an active site within a tunnel formed by two extended loops, which are known to open and close in response to ligand binding. Here we present five structures of wild-type and mutant forms of Cel6A from Humicola insolens in complex with nonhydrolyzable thio-oligosaccharides, at resolutions from 1.7-1.1 A, dissecting the structural accommodation of a processing substrate chain through the active center during hydrolysis. Movement of ligand is facilitated by extensive solvent-mediated interactions and through flexibility in the hydrophobic surfaces provided by a sheath of tryptophan residues.
+The line below this paragraph, {{ABSTRACT_PUBMED_12842048}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12842048 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12842048}}
 ==About this Structure==
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 [[Category: Hydrolase]]
 [[Category: Processive mechanism]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:39:23 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:52:11 2008''