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| {{STRUCTURE_2qqh| PDB=2qqh | SCENE= }} | | {{STRUCTURE_2qqh| PDB=2qqh | SCENE= }} |
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| '''Structure of C8a-MACPF reveals mechanism of membrane attack in complement immune defense'''
| | ===Structure of C8a-MACPF reveals mechanism of membrane attack in complement immune defense=== |
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| ==Overview==
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| Membrane attack is important for mammalian immune defense against invading microorganisms and infected host cells. Proteins of the complement membrane attack complex (MAC) and the protein perforin share a common MACPF domain that is responsible for membrane insertion and pore formation. We determined the crystal structure of the MACPF domain of complement component C8alpha at 2.5 angstrom resolution and show that it is structurally homologous to the bacterial, pore-forming, cholesterol-dependent cytolysins. The structure displays two regions that (in the bacterial cytolysins) refold into transmembrane beta hairpins, forming the lining of a barrel pore. Local hydrophobicity explains why C8alpha is the first complement protein to insert into the membrane. The size of the MACPF domain is consistent with known C9 pore sizes. These data imply that these mammalian and bacterial cytolytic proteins share a common mechanism of membrane insertion.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17872444}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17872444 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17872444}} |
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| ==Disease== | | ==Disease== |
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| [[Category: Polymorphism]] | | [[Category: Polymorphism]] |
| [[Category: Secreted]] | | [[Category: Secreted]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:25:16 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:36:41 2008'' |