1yrs: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:1yrs.jpg|left|200px]]
+{{Seed}}
+[[Image:1yrs.png|left|200px]]
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 {{STRUCTURE_1yrs|  PDB=1yrs  |  SCENE=  }}
-'''Crystal structure of KSP in complex with inhibitor 1'''
+===Crystal structure of KSP in complex with inhibitor 1===
-==Overview==
+<!--
-Optimization of high-throughput screening (HTS) hits resulted in the discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of KSP. Dihydropyrazole 15 is a potent, cell-active KSP inhibitor that induces apoptosis and generates aberrant mitotic spindles in human ovarian carcinoma cells at low nanomolar concentrations. X-ray crystallographic evidence is presented which demonstrates that these inhibitors bind in an allosteric pocket of KSP distant from the nucleotide and microtubule binding sites.
+The line below this paragraph, {{ABSTRACT_PUBMED_15808464}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15808464 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15808464}}
 ==About this Structure==
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 [[Category: Yan, Y.]]
 [[Category: Cell cycle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:41:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:24:39 2008''