2orh: Difference between revisions

Revision as of 12:04, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2orh.png

Template:STRUCTURE 2orh

Directing Macromolecular Conformation Through Halogen BondsDirecting Macromolecular Conformation Through Halogen Bonds

Template:ABSTRACT PUBMED 17379665

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Directing macromolecular conformation through halogen bonds., Voth AR, Hays FA, Ho PS, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6188-93. Epub 2007 Mar 22. PMID:17379665

Page seeded by OCA on Mon Jul 28 12:04:07 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2orh.gif|left|200px]]
+{{Seed}}
+[[Image:2orh.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2orh|  PDB=2orh  |  SCENE=  }}
-'''Directing Macromolecular Conformation Through Halogen Bonds'''
+===Directing Macromolecular Conformation Through Halogen Bonds===
-==Overview==
+<!--
-The halogen bond, a noncovalent interaction involving polarizable chlorine, bromine, or iodine molecular substituents, is now being exploited to control the assembly of small molecules in the design of supramolecular complexes and new materials. We demonstrate that a halogen bond formed between a brominated uracil and phosphate oxygen can be engineered to direct the conformation of a biological molecule, in this case to define the conformational isomer of a four-stranded DNA junction when placed in direct competition against a classic hydrogen bond. As a result, this bromine interaction is estimated to be approximately 2-5 kcal/mol stronger than the analogous hydrogen bond in this environment, depending on the geometry of the halogen bond. This study helps to establish halogen bonding as a potential tool for the rational design and construction of molecular materials with DNA and other biological macromolecules.
+The line below this paragraph, {{ABSTRACT_PUBMED_17379665}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17379665 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17379665}}
 ==About this Structure==
@@ Line 25: / Line 29: @@
 [[Category: Dna holliday junction]]
 [[Category: Halogen bond]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 11:31:10 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:04:07 2008''