1oke: Difference between revisions

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OCA

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-[[Image:1oke.gif|left|200px]]
+{{Seed}}
+[[Image:1oke.png|left|200px]]
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 {{STRUCTURE_1oke|  PDB=1oke  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN IN COMPLEX WITH N-OCTYL-BETA-D-GLUCOSIDE'''
+===CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN IN COMPLEX WITH N-OCTYL-BETA-D-GLUCOSIDE===
-==Overview==
+<!--
-Dengue virus is an emerging global health threat. Its major envelope glycoprotein, E, mediates viral attachment and entry by membrane fusion. A crystal structure of the soluble ectodomain of E from dengue virus type 2 reveals a hydrophobic pocket lined by residues that influence the pH threshold for fusion. The pocket, which accepts a hydrophobic ligand, opens and closes through a conformational shift in a beta-hairpin at the interface between two domains. These features point to a structural pathway for the fusion-activating transition and suggest a strategy for finding small-molecule inhibitors of dengue and other flaviviruses.
+The line below this paragraph, {{ABSTRACT_PUBMED_12759475}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12759475 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12759475}}
 ==About this Structure==
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 [[Category: Trimer]]
 [[Category: Virus/viral protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:57:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:19:56 2008''