2j1z: Difference between revisions

Revision as of 11:18, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2j1z.png

Template:STRUCTURE 2j1z

HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-F270LHUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-F270L

Template:ABSTRACT PUBMED 17015838

About this StructureAbout this Structure

2J1Z is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs., Joerger AC, Ang HC, Fersht AR, Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838

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OCA

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-'''HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-F270L'''
+===HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-F270L===
-==Overview==
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-The DNA-binding domain of the tumor suppressor p53 is inactivated by mutation in approximately 50% of human cancers. We have solved high-resolution crystal structures of several oncogenic mutants to investigate the structural basis of inactivation and provide information for designing drugs that may rescue inactivated mutants. We found a variety of structural consequences upon mutation: (i) the removal of an essential contact with DNA, (ii) creation of large, water-accessible crevices or hydrophobic internal cavities with no other structural changes but with a large loss of thermodynamic stability, (iii) distortion of the DNA-binding surface, and (iv) alterations to surfaces not directly involved in DNA binding but involved in domain-domain interactions on binding as a tetramer. These findings explain differences in functional properties and associated phenotypes (e.g., temperature sensitivity). Some mutants have the potential of being rescued by a generic stabilizing drug. In addition, a mutation-induced crevice is a potential target site for a mutant-selective stabilizing drug.
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 [[Category: Tumor suppressor]]
 [[Category: Zinc]]
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