2i47: Difference between revisions

Revision as of 11:17, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2i47.png

Template:STRUCTURE 2i47

Crystal structure of catalytic domain of TACE with inhibitorCrystal structure of catalytic domain of TACE with inhibitor

Template:ABSTRACT PUBMED 17064892

About this StructureAbout this Structure

2I47 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Identification of potent and selective TACE inhibitors via the S1 pocket., Condon JS, Joseph-McCarthy D, Levin JI, Lombart HG, Lovering FE, Sun L, Wang W, Xu W, Zhang Y, Bioorg Med Chem Lett. 2007 Jan 1;17(1):34-9. Epub 2006 Oct 5. PMID:17064892

Page seeded by OCA on Mon Jul 28 11:17:29 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2i47.gif|left|200px]]
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 {{STRUCTURE_2i47|  PDB=2i47  |  SCENE=  }}
-'''Crystal structure of catalytic domain of TACE with inhibitor'''
+===Crystal structure of catalytic domain of TACE with inhibitor===
-==Overview==
+<!--
-By focusing on the P1 portion of the piperidine beta-sulfone ligands we identified a motif that induces selectivity and resulted in a series of TACE inhibitors that demonstrated excellent in vitro potency against isolated TACE enzyme and excellent selectivity over MMPs 1, 2, 9, 13, and 14.
+The line below this paragraph, {{ABSTRACT_PUBMED_17064892}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_17064892}}
 ==About this Structure==
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 [[Category: Tace-inhibitor complex]]
 [[Category: Tace/adam-17]]
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