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| {{STRUCTURE_2rgn| PDB=2rgn | SCENE= }} | | {{STRUCTURE_2rgn| PDB=2rgn | SCENE= }} |
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| '''Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA'''
| | ===Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA=== |
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| ==Overview==
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| The guanine nucleotide exchange factor p63RhoGEF is an effector of the heterotrimeric guanine nucleotide-binding protein (G protein) Galphaq and thereby links Galphaq-coupled receptors (GPCRs) to the activation of the small-molecular-weight G protein RhoA. We determined the crystal structure of the Galphaq-p63RhoGEF-RhoA complex, detailing the interactions of Galphaq with the Dbl and pleckstrin homology (DH and PH) domains of p63RhoGEF. These interactions involve the effector-binding site and the C-terminal region of Galphaq and appear to relieve autoinhibition of the catalytic DH domain by the PH domain. Trio, Duet, and p63RhoGEF are shown to constitute a family of Galphaq effectors that appear to activate RhoA both in vitro and in intact cells. We propose that this structure represents the crux of an ancient signal transduction pathway that is expected to be important in an array of physiological processes. | | The line below this paragraph, {{ABSTRACT_PUBMED_18096806}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 18096806 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_18096806}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Small molecular weight g-protein]] | | [[Category: Small molecular weight g-protein]] |
| [[Category: Transducer]] | | [[Category: Transducer]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:52:55 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:12:32 2008'' |