2h7e: Difference between revisions

Revision as of 11:10, 28 July 2008

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File:2h7e.png

Template:STRUCTURE 2h7e

Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide- minimized average structureSolution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide- minimized average structure

Template:ABSTRACT PUBMED 17218263

About this StructureAbout this Structure

2H7E is a Protein complex structure of sequences from Gallus gallus. Full experimental information is available from OCA.

ReferenceReference

Structural basis of integrin activation by talin., Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell ID, Cell. 2007 Jan 12;128(1):171-82. PMID:17218263

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-'''Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide- minimized average structure'''
+===Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide- minimized average structure===
-==Overview==
+<!--
-Regulation of integrin affinity (activation) is essential for metazoan development and for many pathological processes. Binding of the talin phosphotyrosine-binding (PTB) domain to integrin beta subunit cytoplasmic domains (tails) causes activation, whereas numerous other PTB-domain-containing proteins bind integrins without activating them. Here we define the structure of a complex between talin and the membrane-proximal integrin beta3 cytoplasmic domain and identify specific contacts between talin and the integrin tail required for activation. We used structure-based mutagenesis to engineer talin and beta3 variants that interact with comparable affinity to the wild-type proteins but inhibit integrin activation by competing with endogenous talin. These results reveal the structural basis of talin's unique ability to activate integrins, identify an interaction that could aid in the design of therapeutics to block integrin activation, and enable engineering of cells with defects in the activation of multiple classes of integrins.
+The line below this paragraph, {{ABSTRACT_PUBMED_17218263}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17218263 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_17218263}}
 ==About this Structure==
-H7E is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H7E OCA].
+H7E is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H7E OCA].
 ==Reference==
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 [[Category: Beta sheet]]
 [[Category: Protein-peptide complex]]
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