2aei: Difference between revisions

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-[[Image:2aei.gif|left|200px]]
+{{Seed}}
+[[Image:2aei.png|left|200px]]
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 {{STRUCTURE_2aei|  PDB=2aei  |  SCENE=  }}
-'''Crystal structure of a ternary complex of factor VIIa/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid'''
+===Crystal structure of a ternary complex of factor VIIa/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid===
-==Overview==
+<!--
-The activated Factor VII/tissue factor complex (FVIIa/TF) plays a key role in the formation of blood clots. Inhibition of this complex may lead to new antithrombotic drugs. An X-ray crystal structure of a fluoropyridine-based FVIIa/TF inhibitor bound in the active site of the enzyme complex suggested that incorporation of substitution at the 5-position of the hydroxybenzoic acid side chain could lead to the formation of more potent inhibitors through interactions with the S1'/S2' pocket.
+The line below this paragraph, {{ABSTRACT_PUBMED_16125385}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16125385 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16125385}}
 ==Disease==
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 [[Category: Thrombosis]]
 [[Category: Tissue factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:56:53 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:09:39 2008''