2bt0: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:2bt0.gif|left|200px]]
+{{Seed}}
+[[Image:2bt0.png|left|200px]]
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 {{STRUCTURE_2bt0|  PDB=2bt0  |  SCENE=  }}
-'''NOVEL, POTENT SMALL MOLECULE INHIBITORS OF THE MOLECULAR CHAPERONE HSP90 DISCOVERED THROUGH STRUCTURE-BASED DESIGN'''
+===NOVEL, POTENT SMALL MOLECULE INHIBITORS OF THE MOLECULAR CHAPERONE HSP90 DISCOVERED THROUGH STRUCTURE-BASED DESIGN===
-==Overview==
+<!--
-The crystal structure of a previously reported screening hit 1 (CCT018159) bound to the N terminal domain of molecular chaperone Hsp90 has been used to design 5-amide analogues. These exhibit enhanced potency against the target in binding and functional assays with accompanying appropriate cellular pharmacodynamic changes. Compound 11 (VER-49009) compares favorably with the clinically evaluated 17-AAG.
+The line below this paragraph, {{ABSTRACT_PUBMED_15974572}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15974572 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15974572}}
 ==About this Structure==
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 [[Category: Heat shock]]
 [[Category: Phosphorylation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:45:29 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:49:01 2008''