1o0d: Difference between revisions

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{{Seed}}
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{{STRUCTURE_1o0d|  PDB=1o0d  |  SCENE=  }}  
{{STRUCTURE_1o0d|  PDB=1o0d  |  SCENE=  }}  


'''Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor'''
===Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor===




==Overview==
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Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin-inhibitor complex X-ray structures.
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{{ABSTRACT_PUBMED_12781189}}


==Disease==
==Disease==
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[[Category: Ternary complex]]
[[Category: Ternary complex]]
[[Category: Thrombin/active-site inhibitor/exo-site inhibitor]]
[[Category: Thrombin/active-site inhibitor/exo-site inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:12:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:45:50 2008''

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