1qxk: Difference between revisions

Revision as of 10:42, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1qxk.png

Template:STRUCTURE 1qxk

Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1BMonoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B

Template:ABSTRACT PUBMED 14592481

About this StructureAbout this Structure

1QXK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B., Xin Z, Liu G, Abad-Zapatero C, Pei Z, Szczepankiewicz BG, Li X, Zhang T, Hutchins CW, Hajduk PJ, Ballaron SJ, Stashko MA, Lubben TH, Trevillyan JM, Jirousek MR, Bioorg Med Chem Lett. 2003 Nov 17;13(22):3947-50. PMID:14592481

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OCA

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-'''Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B'''
+===Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B===
-==Overview==
+<!--
-Monoacid-based PTP1B inhibitors with improved physiochemical properties have been investigated. A (2-hydroxy-phenoxy) acetic acid-based phosphotyrosyl mimetic has been linked with an optimized second arylphosphate binding site ligand to produce compound 20 with low micromolar potency against PTP1B, good selectivity over TCPTP (20-fold) and high cell permeability in the Caco-2 system.
+The line below this paragraph, {{ABSTRACT_PUBMED_14592481}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14592481 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14592481}}
 ==About this Structure==
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 [[Category: Protein tyrosine phosphatase 1b]]
 [[Category: Ptp1b monoacid-based and cell permeable]]
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