1sm2: Difference between revisions

Revision as of 10:31, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1sm2.png

Template:STRUCTURE 1sm2

Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domainCrystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain

Template:ABSTRACT PUBMED 14766749

About this StructureAbout this Structure

1SM2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors., Brown K, Long JM, Vial SC, Dedi N, Dunster NJ, Renwick SB, Tanner AJ, Frantz JD, Fleming MA, Cheetham GM, J Biol Chem. 2004 Apr 30;279(18):18727-32. Epub 2004 Feb 6. PMID:14766749

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OCA

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-'''Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain'''
+===Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain===
-==Overview==
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-Interleukin-2 tyrosine kinase, Itk, is an important member of the Tec family of non-receptor tyrosine kinases that play a central role in signaling through antigen receptors such as the T-cell receptor, B-cell receptor, and Fcepsilon. Selective inhibition of Itk may be an important way of modulating many diseases involving heightened or inappropriate activation of the immune system. In addition to an unliganded nonphophorylated Itk catalytic kinase domain, we determined the crystal structures of the phosphorylated and nonphosphorylated kinase domain bound to staurosporine, a potent broad-spectrum kinase inhibitor. These structures are useful for the design of novel, highly potent and selective Itk inhibitors and provide insight into the influence of inhibitor binding and phosphorylation on the conformation of Itk.
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 ==About this Structure==
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 [[Category: Immunology]]
 [[Category: Protein kinase]]
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