2q2u: Difference between revisions

Revision as of 10:18, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2q2u.png

Template:STRUCTURE 2q2u

Structure of Chlorella virus DNA ligase-product DNA complexStructure of Chlorella virus DNA ligase-product DNA complex

Template:ABSTRACT PUBMED 17618295

About this StructureAbout this Structure

2Q2U is a Single protein structure of sequence from Paramecium bursaria chlorella virus 1. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for nick recognition by a minimal pluripotent DNA ligase., Nair PA, Nandakumar J, Smith P, Odell M, Lima CD, Shuman S, Nat Struct Mol Biol. 2007 Aug;14(8):770-8. Epub 2007 Jul 8. PMID:17618295

Page seeded by OCA on Mon Jul 28 10:18:36 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Structure of Chlorella virus DNA ligase-product DNA complex'''
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-==Overview==
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-Chlorella virus DNA ligase, the smallest eukaryotic ligase known, has pluripotent biological activity and an intrinsic nick-sensing function, despite having none of the accessory domains found in cellular ligases. A 2.3-A crystal structure of the Chlorella virus ligase-AMP intermediate bound to duplex DNA containing a 3'-OH-5'-PO4 nick reveals a new mode of DNA envelopment, in which a short surface loop emanating from the OB domain forms a beta-hairpin 'latch' that inserts into the DNA major groove flanking the nick. A network of interactions with the 3'-OH and 5'-PO4 termini in the active site illuminates the DNA adenylylation mechanism and the crucial roles of AMP in nick sensing and catalysis. Addition of a divalent cation triggered nick sealing in crystallo, establishing that the nick complex is a bona fide intermediate in the DNA repair pathway.
+The line below this paragraph, {{ABSTRACT_PUBMED_17618295}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_17618295}}
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 [[Category: Product-complex]]
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