1sy6: Difference between revisions

Revision as of 10:07, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1sy6.png

Template:STRUCTURE 1sy6

Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab FragmentCrystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment

Template:ABSTRACT PUBMED 15136729

About this StructureAbout this Structure

1SY6 is a Single protein structure of sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3., Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely LK, Beddoe T, Mifsud NA, Purcell AW, Brooks AG, McCluskey J, Rossjohn J, Proc Natl Acad Sci U S A. 2004 May 18;101(20):7675-80. Epub 2004 May 10. PMID:15136729

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment'''
+===Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment===
-==Overview==
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-The CD3 epsilon gamma heterodimer is essential for expression and function of the T cell receptor. The crystal structure of the human CD3 epsilon gamma heterodimer is described to 2.1-A resolution complexed with OKT3, a therapeutic mAb that not only activates and tolerizes mature T cells but also induces regulatory T cells. The mode of CD3 epsilon gamma dimerization provides a general structural basis for CD3 assembly and maps candidate T cell antigen receptor docking sites, including a duplicated linear region rich in acidic residues that is unique to human CD3 epsilon. OKT3 binds to an atypically small area of CD3 epsilon and has a low affinity for the isolated CD3 epsilon gamma heterodimer. The structure of the OKT3/CD3 epsilon gamma complex has implications for T cell signaling and therapeutic design.
+The line below this paragraph, {{ABSTRACT_PUBMED_15136729}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_15136729}}
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 [[Category: Cd3 gamma]]
 [[Category: Okt3 fab]]
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