1n67: Difference between revisions

Revision as of 10:03, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1n67.png

Template:STRUCTURE 1n67

Clumping Factor A from Staphylococcus aureusClumping Factor A from Staphylococcus aureus

Template:ABSTRACT PUBMED 12485987

About this StructureAbout this Structure

1N67 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

ReferenceReference

A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen-binding MSCRAMM, clumping factor A., Deivanayagam CC, Wann ER, Chen W, Carson M, Rajashankar KR, Hook M, Narayana SV, EMBO J. 2002 Dec 16;21(24):6660-72. PMID:12485987

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OCA

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-'''Clumping Factor A from Staphylococcus aureus'''
+===Clumping Factor A from Staphylococcus aureus===
-==Overview==
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-We report here the crystal structure of the minimal ligand-binding segment of the Staphylococcus aureus MSCRAMM, clumping factor A. This fibrinogen-binding segment contains two similarly folded domains. The fold observed is a new variant of the immunoglobulin motif that we have called DE-variant or the DEv-IgG fold. This subgroup includes the ligand-binding domain of the collagen-binding S.aureus MSCRAMM CNA, and many other structures previously classified as jelly rolls. Structure predictions suggest that the four fibrinogen-binding S.aureus MSCRAMMs identified so far would also contain the same DEv-IgG fold. A systematic docking search using the C-terminal region of the fibrinogen gamma-chain as a probe suggested that a hydrophobic pocket formed between the two DEv-IgG domains of the clumping factor as the ligand-binding site. Mutagenic substitution of residues Tyr256, Pro336, Tyr338 and Lys389 in the clumping factor, which are proposed to contact the terminal residues (408)AGDV(411) of the gamma-chain, resulted in proteins with no or markedly reduced affinity for fibrinogen.
+The line below this paragraph, {{ABSTRACT_PUBMED_12485987}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_12485987}}
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 [[Category: Immunoglobulin]]
 [[Category: Staphylococcus aureus]]
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