1uru: Difference between revisions

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-[[Image:1uru.gif|left|200px]]
+{{Seed}}
+[[Image:1uru.png|left|200px]]
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 {{STRUCTURE_1uru|  PDB=1uru  |  SCENE=  }}
-'''AMPHIPHYSIN BAR DOMAIN FROM DROSOPHILA'''
+===AMPHIPHYSIN BAR DOMAIN FROM DROSOPHILA===
-==Overview==
+<!--
-The BAR (Bin/amphiphysin/Rvs) domain is the most conserved feature in amphiphysins from yeast to human and is also found in endophilins and nadrins. We solved the structure of the Drosophila amphiphysin BAR domain. It is a crescent-shaped dimer that binds preferentially to highly curved negatively charged membranes. With its N-terminal amphipathic helix and BAR domain (N-BAR), amphiphysin can drive membrane curvature in vitro and in vivo. The structure is similar to that of arfaptin2, which we find also binds and tubulates membranes. From this, we predict that BAR domains are in many protein families, including sorting nexins, centaurins, and oligophrenins. The universal and minimal BAR domain is a dimerization, membrane-binding, and curvature-sensing module.
+The line below this paragraph, {{ABSTRACT_PUBMED_14645856}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14645856 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14645856}}
 ==About this Structure==
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 [[Category: Endocytosis]]
 [[Category: Membrane curvature]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:36:11 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:51:42 2008''