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| {{STRUCTURE_3bw9| PDB=3bw9 | SCENE= }} | | {{STRUCTURE_3bw9| PDB=3bw9 | SCENE= }} |
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| '''Crystal Structure of HLA B*3508 in complex with a HCMV 12-mer peptide from the pp65 protein'''
| | ===Crystal Structure of HLA B*3508 in complex with a HCMV 12-mer peptide from the pp65 protein=== |
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| ==Overview==
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| CD8(+) T-cell responses to persistent viral infections are characterized by the accumulation of an oligoclonal T-cell repertoire and a reduction in the naive T-cell pool. However, the precise mechanism for this phenomenon remains elusive. Here we show that human cytomegalovirus (HCMV)-specific CD8(+) T cells recognizing distinct epitopes from the pp65 protein and restricted through an identical HLA class I allele (HLA B*3508) exhibited either a highly conserved public T-cell repertoire or a private, diverse T-cell response, which was uniquely altered in each donor following in vitro antigen exposure. Selection of a public T-cell receptor (TCR) was coincident with an atypical major histocompatibility complex (MHC)-peptide structure, in that the epitope adopted a helical conformation that bulged from the peptide-binding groove, while a diverse TCR profile was observed in response to the epitope that formed a flatter, more "featureless" landscape. Clonotypes with biased TCR usage demonstrated more efficient recognition of virus-infected cells, a greater CD8 dependency, and were more terminally differentiated in their phenotype when compared with the T cells expressing diverse TCR. These findings provide new insights into our understanding on how the biology of antigen presentation in addition to the structural features of the pMHC-I might shape the T-cell repertoire and its phenotype.
| | The line below this paragraph, {{ABSTRACT_PUBMED_18270323}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 18270323 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_18270323}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Viral matrix protein]] | | [[Category: Viral matrix protein]] |
| [[Category: Virion]] | | [[Category: Virion]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:49:42 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:50:55 2008'' |
