2btr: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:2btr.gif|left|200px]]
+{{Seed}}
+[[Image:2btr.png|left|200px]]
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 {{STRUCTURE_2btr|  PDB=2btr  |  SCENE=  }}
-'''STRUCTURE OF CDK2 COMPLEXED WITH PNU-198873'''
+===STRUCTURE OF CDK2 COMPLEXED WITH PNU-198873===
-==Overview==
+<!--
-N-(5-Bromo-1,3-thiazol-2-yl)butanamide (compound 1) was found active (IC50=808 nM) in a high throughput screening (HTS) for CDK2 inhibitors. By exploiting crystal structures of several complexes between CDK2 and inhibitors and applying structure-based drug design (SBDD), we rapidly discovered a very potent and selective CDK2 inhibitor 4-[(5-isopropyl-1,3-thiazol-2-yl)amino] benzenesulfonamide (compound 4, IC50=20 nM). The syntheses, structure-based analog design, kinases inhibition data and X-ray crystallographic structures of CDK2/inhibitor complexes are reported.
+The line below this paragraph, {{ABSTRACT_PUBMED_16260160}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16260160 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16260160}}
 ==About this Structure==
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 [[Category: Serine/threonine-protein 2 kinase]]
 [[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:47:15 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:38:02 2008''