1vif: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:1vif.jpg|left|200px]]
+{{Seed}}
+[[Image:1vif.png|left|200px]]
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 {{STRUCTURE_1vif|  PDB=1vif  |  SCENE=  }}
-'''STRUCTURE OF DIHYDROFOLATE REDUCTASE'''
+===STRUCTURE OF DIHYDROFOLATE REDUCTASE===
-==Overview==
+<!--
-Bacteria expressing R67-plasmid encoded dihydrofolate reductase (R67 DHFR) exhibit high-level resistance to the antibiotic trimethoprim. Native R67 DHFR is a 34,000 M(r) homotetramer which exists in equilibrium with an inactive dimeric form. The structure of native R67 DHFR has now been solved at 1.7 A resolution and is unrelated to that of chromosomal DHFR. Homotetrameric R67 DHFR has an unusual pore, 25 A in length, passing through the middle of the molecule. Two folate molecules bind asymmetrically within the pore indicating that the enzyme's active site consists of symmetry related binding surfaces from all four identical units.
+The line below this paragraph, {{ABSTRACT_PUBMED_7583655}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7583655 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7583655}}
 ==About this Structure==
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 [[Category: Plasmid]]
 [[Category: Trimethoprim resistance methotrexate resistance]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:34:02 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:51:43 2008''