1qlf: Difference between revisions

Revision as of 08:30, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1qlf.png

Template:STRUCTURE 1qlf

MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3GMHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G

Template:ABSTRACT PUBMED 10023771

About this StructureAbout this Structure

1QLF is a Protein complex structure of sequences from Homo sapiens, Mus musculus and Sendai virus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity., Glithero A, Tormo J, Haurum JS, Arsequell G, Valencia G, Edwards J, Springer S, Townsend A, Pao YL, Wormald M, Dwek RA, Jones EY, Elliott T, Immunity. 1999 Jan;10(1):63-74. PMID:10023771

Page seeded by OCA on Mon Jul 28 08:30:11 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1qlf.jpg|left|200px]]
+{{Seed}}
+[[Image:1qlf.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1qlf|  PDB=1qlf  |  SCENE=  }}
-'''MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G'''
+===MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G===
-==Overview==
+<!--
-Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. Here, we present the crystal structures of the H-2Db glycopeptide complexes to 2.85 A resolution or better. In both cases, the glycan is solvent exposed and available for direct recognition by the T cell receptor (TCR). We have modeled the complex formed between the MHC-glycopeptide complexes and their respective TCRs, showing that a single saccharide residue can be accommodated in the standard TCR-MHC geometry. The models also reveal a possible molecular basis for the observed cross-reactivity patterns of the CTL clones, which appear to be influenced by the length of the CDR3 loop and the nature of the immunizing ligand.
+The line below this paragraph, {{ABSTRACT_PUBMED_10023771}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10023771 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10023771}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Immunology]]
 [[Category: Mhc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:24:47 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:30:11 2008''