2g2f: Difference between revisions

Revision as of 07:39, 28 July 2008

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File:2g2f.png

Template:STRUCTURE 2g2f

A Src-like Inactive Conformation in the Abl Tyrosine Kinase DomainA Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain

Template:ABSTRACT PUBMED 16640460

About this StructureAbout this Structure

2G2F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

A Src-like inactive conformation in the abl tyrosine kinase domain., Levinson NM, Kuchment O, Shen K, Young MA, Koldobskiy M, Karplus M, Cole PA, Kuriyan J, PLoS Biol. 2006 May;4(5):e144. Epub 2006 May 2. PMID:16640460

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OCA

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-'''A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain'''
+===A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain===
-==Overview==
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-The improper activation of the Abl tyrosine kinase results in chronic myeloid leukemia (CML). The recognition of an inactive conformation of Abl, in which a catalytically important Asp-Phe-Gly (DFG) motif is flipped by approximately 180 degrees with respect to the active conformation, underlies the specificity of the cancer drug imatinib, which is used to treat CML. The DFG motif is not flipped in crystal structures of inactive forms of the closely related Src kinases, and imatinib does not inhibit c-Src. We present a structure of the kinase domain of Abl, determined in complex with an ATP-peptide conjugate, in which the protein adopts an inactive conformation that resembles closely that of the Src kinases. An interesting aspect of the Src-like inactive structure, suggested by molecular dynamics simulations and additional crystal structures, is the presence of features that might facilitate the flip of the DFG motif by providing room for the phenylalanine to move and by coordinating the aspartate side chain as it leaves the active site. One class of mutations in BCR-Abl that confers resistance to imatinib appears more likely to destabilize the inactive Src-like conformation than the active or imatinib-bound conformations. Our results suggest that interconversion between distinctly different inactive conformations is a characteristic feature of the Abl kinase domain.
+The line below this paragraph, {{ABSTRACT_PUBMED_16640460}}, adds the Publication Abstract to the page
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 ==About this Structure==
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 [[Category: Levinson, N M.]]
 [[Category: Protein kinase]]
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