2gn3: Difference between revisions

Revision as of 07:38, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2gn3.png

Template:STRUCTURE 2gn3

Metal-free (apo-PAL) in complex with alpha-D-Met-ManMetal-free (apo-PAL) in complex with alpha-D-Met-Man

Template:ABSTRACT PUBMED 16824540

About this StructureAbout this Structure

2GN3 is a Single protein structure of sequence from Pterocarpus angolensis. Full crystallographic information is available from OCA.

ReferenceReference

Interplay between metal binding and cis/trans isomerization in legume lectins: structural and thermodynamic study of P. angolensis lectin., Garcia-Pino A, Buts L, Wyns L, Loris R, J Mol Biol. 2006 Aug 4;361(1):153-67. Epub 2006 Jun 21. PMID:16824540

Page seeded by OCA on Mon Jul 28 07:38:21 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Metal-free (apo-PAL) in complex with alpha-D-Met-Man'''
+===Metal-free (apo-PAL) in complex with alpha-D-Met-Man===
-==Overview==
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-The interplay between metal binding, carbohydrate binding activity, stability and structure of the lectin from Pterocarpus angolensis was investigated. Removal of the metals leads to a more flexible form of the protein with significantly less conformational stability. Crystal structures of this metal-free form show significant structural rearrangements, although some structural features that allow the binding of sugars are retained. We propose that substitution of an asparagine residue at the start of the C-terminal beta-strand of the legume lectin monomer hinders the trans-isomerization of the cis-peptide bond upon demetallization and constitutes an intramolecular switch governing the isomer state of the non-proline bond and ultimately the lectin phenotype.
+The line below this paragraph, {{ABSTRACT_PUBMED_16824540}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_16824540}}
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 [[Category: Metal-free lectin]]
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