1r02: Difference between revisions

Revision as of 07:01, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1r02.png

Template:STRUCTURE 1r02

Solution structure of Human Orexin-A:Regulator of Appetite and WakefulnessSolution structure of Human Orexin-A:Regulator of Appetite and Wakefulness

Template:ABSTRACT PUBMED 15479620

About this StructureAbout this Structure

1R02 is a Single protein structure. Full experimental information is available from OCA.

ReferenceReference

Solution structure of human orexin-A: regulator of appetite and wakefulness., Kim HY, Hong E, Kim JI, Lee W, J Biochem Mol Biol. 2004 Sep 30;37(5):565-73. PMID:15479620

Page seeded by OCA on Mon Jul 28 07:00:58 2008

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OCA

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-[[Image:1r02.gif|left|200px]]
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-'''Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness'''
+===Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness===
-==Overview==
+<!--
-Orexin-A and orexin-B (hypocretin-1 and hypocretin-2, respectively) are important hypothalamic neuro-peptides, which are encoded by a single mRNA transcript and stimulate food intake as well as regulate wakefulness. Here we determined the solution structure of orexin-A by NMR spectroscopy and by simulated-annealing calculation. The structural features of orexin-A involve two alpha-helices, with the hydrophobic residues disposed to on one side of helix, and hydrophilic residues to the other. A hydrophilic turn induced by two disulfide bonds provides the key difference between orexin-A and -B. With previous mutagenic studies, the derived structure of orexin-A provides us with a structure-functional view for novel drug design.
+The line below this paragraph, {{ABSTRACT_PUBMED_15479620}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15479620 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15479620}}
 ==About this Structure==
-R02 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA].
+R02 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA].
 ==Reference==
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 [[Category: Helix-loop-helix]]
 [[Category: Turn]]
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+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:00:58 2008''