2a8h: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:2a8h.gif|left|200px]]
+{{Seed}}
+[[Image:2a8h.png|left|200px]]
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 {{STRUCTURE_2a8h|  PDB=2a8h  |  SCENE=  }}
-'''Crystal structure of catalytic domain of TACE with Thiomorpholine Sulfonamide Hydroxamate inhibitor'''
+===Crystal structure of catalytic domain of TACE with Thiomorpholine Sulfonamide Hydroxamate inhibitor===
-==Overview==
+<!--
-A series of thiomorpholine sulfonamide hydroxamate TACE inhibitors, all bearing propargylic ether P1' groups, was explored. In particular, compound 5h has excellent in vitro potency against isolated TACE enzyme and in cells, oral activity in a model of TNF-alpha production and a collagen-induced arthritis model, was selected as a clinical candidate for the treatment of RA.
+The line below this paragraph, {{ABSTRACT_PUBMED_16426848}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16426848 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16426848}}
 ==About this Structure==
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 [[Category: Tace/adam-17]]
 [[Category: Zn-endopeptidase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:44:38 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:56:01 2008''