2g20: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:2g20.gif|left|200px]]
+{{Seed}}
+[[Image:2g20.png|left|200px]]
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 {{STRUCTURE_2g20|  PDB=2g20  |  SCENE=  }}
-'''Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring'''
+===Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring===
-==Overview==
+<!--
-A systematic investigation of the S3 sub-pocket activity requirements was conducted. It was observed that linear and sterically small side chain substituents are preferred in the S3 sub-pocket for optimal renin inhibition. Polar groups in the S3-sub-pocket were not well tolerated and caused a reduction in renin inhibitory activity. Further, compounds with clog P's &lt; or = 3 demonstrated a dramatic reduction in CYP3A4 inhibitory activity.
+The line below this paragraph, {{ABSTRACT_PUBMED_16480874}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16480874 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16480874}}
 ==Disease==
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 [[Category: Zhanga, E.]]
 [[Category: Protein-ligand complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:36:14 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:14:08 2008''