1yze: Difference between revisions

Revision as of 04:57, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1yze.png

Template:STRUCTURE 1yze

Crystal structure of the N-terminal domain of USP7/HAUSP.Crystal structure of the N-terminal domain of USP7/HAUSP.

Template:ABSTRACT PUBMED 15808506

About this StructureAbout this Structure

1YZE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization., Saridakis V, Sheng Y, Sarkari F, Holowaty MN, Shire K, Nguyen T, Zhang RG, Liao J, Lee W, Edwards AM, Arrowsmith CH, Frappier L, Mol Cell. 2005 Apr 1;18(1):25-36. PMID:15808506

Page seeded by OCA on Mon Jul 28 04:57:50 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1yze.gif|left|200px]]
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 {{STRUCTURE_1yze|  PDB=1yze  |  SCENE=  }}
-'''Crystal structure of the N-terminal domain of USP7/HAUSP.'''
+===Crystal structure of the N-terminal domain of USP7/HAUSP.===
-==Overview==
+<!--
-USP7/HAUSP is a key regulator of p53 and Mdm2 and is targeted by the Epstein-Barr nuclear antigen 1 (EBNA1) protein of Epstein-Barr virus (EBV). We have determined the crystal structure of the p53 binding domain of USP7 alone and bound to an EBNA1 peptide. This domain is an eight-stranded beta sandwich similar to the TRAF-C domains of TNF-receptor associated factors, although the mode of peptide binding differs significantly from previously observed TRAF-peptide interactions in the sequence (DPGEGPS) and the conformation of the bound peptide. NMR chemical shift analyses of USP7 bound by EBNA1 and p53 indicated that p53 binds the same pocket as EBNA1 but makes less extensive contacts with USP7. Functional studies indicated that EBNA1 binding to USP7 can protect cells from apoptotic challenge by lowering p53 levels. The data provide a structural and conceptual framework for understanding how EBNA1 might contribute to the survival of Epstein-Barr virus-infected cells.
+The line below this paragraph, {{ABSTRACT_PUBMED_15808506}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15808506 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15808506}}
 ==About this Structure==
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 [[Category: Deubiquitinating enzyme]]
 [[Category: Traf domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:59:56 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:57:50 2008''