1nos: Difference between revisions

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-[[Image:1nos.jpg|left|200px]]
+{{Seed}}
+[[Image:1nos.png|left|200px]]
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 {{STRUCTURE_1nos|  PDB=1nos  |  SCENE=  }}
-'''MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114), IMIDAZOLE COMPLEX'''
+===MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114), IMIDAZOLE COMPLEX===
-==Overview==
+<!--
-The nitric oxide synthase oxygenase domain (NOSox) oxidizes arginine to synthesize the cellular signal and defensive cytotoxin nitric oxide (NO). Crystal structures determined for cytokine-inducible NOSox reveal an unusual fold and heme environment for stabilization of activated oxygen intermediates key for catalysis. A winged beta sheet engenders a curved alpha-beta domain resembling a baseball catcher's mitt with heme clasped in the palm. The location of exposed hydrophobic residues and the results of mutational analysis place the dimer interface adjacent to the heme-binding pocket. Juxtaposed hydrophobic O2- and polar L-arginine-binding sites occupied by imidazole and aminoguanidine, respectively, provide a template for designing dual-function inhibitors and imply substrate-assisted catalysis.
+The line below this paragraph, {{ABSTRACT_PUBMED_9334294}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9334294 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9334294}}
 ==About this Structure==
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 [[Category: No]]
 [[Category: Oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:47:35 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:41:47 2008''