1scj: Difference between revisions

Revision as of 03:55, 28 July 2008

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File:1scj.png

Template:STRUCTURE 1scj

CRYSTAL STRUCTURE OF SUBTILISIN-PROPEPTIDE COMPLEXCRYSTAL STRUCTURE OF SUBTILISIN-PROPEPTIDE COMPLEX

Template:ABSTRACT PUBMED 9811547

About this StructureAbout this Structure

1SCJ is a Protein complex structure of sequences from Bacillus subtilis. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of an autoprocessed Ser221Cys-subtilisin E-propeptide complex at 2.0 A resolution., Jain SC, Shinde U, Li Y, Inouye M, Berman HM, J Mol Biol. 1998 Nov 20;284(1):137-44. PMID:9811547

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OCA

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-'''CRYSTAL STRUCTURE OF SUBTILISIN-PROPEPTIDE COMPLEX'''
+===CRYSTAL STRUCTURE OF SUBTILISIN-PROPEPTIDE COMPLEX===
-==Overview==
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-We report here the crystallographic structure determination of an autoprocessed (Ser221Cys)-subtilisin E-propeptide complex at 2.0 A resolution. The subtilisin domain sequence has a single substitution (Ser221Cys) which has been shown to block the maturation process prior to degradation of the propeptide domain (77 residues) that acts as an intramolecular chaperon. This mutation, however, did not prevent the enzyme from cleaving its propeptide domain with a 60-80% efficiency. The current determination is the first example of a subtilisin E-propeptide complex which has been autoprocessed. A previous structure determination of a BPN'-prosegment complex has been reported in which the subtilisin domain was extensively mutated and a calcium binding loop was deleted. Further, in this earlier determination, the complex was formed by the addition of separately expressed propeptide domain. The structure determination reported here provides additional information about the nature of the interaction between the subtilisin and propeptide domains in this complex.
+The line below this paragraph, {{ABSTRACT_PUBMED_9811547}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9811547 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_9811547}}
 ==About this Structure==
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 [[Category: Serine protease]]
 [[Category: Subtilisin e - propeptide]]
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