3chp: Difference between revisions

Revision as of 03:23, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:3chp.png

Template:STRUCTURE 3chp

Crystal structure of leukotriene a4 hydrolase in complex with (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acidCrystal structure of leukotriene a4 hydrolase in complex with (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acid

Template:ABSTRACT PUBMED 18394906

About this StructureAbout this Structure

3CHP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A(4) hydrolase., Kirkland TA, Adler M, Bauman JG, Chen M, Haeggstrom JZ, King B, Kochanny MJ, Liang AM, Mendoza L, Phillips GB, Thunnissen M, Trinh L, Whitlow M, Ye B, Ye H, Parkinson J, Guilford WJ, Bioorg Med Chem. 2008 Mar 20;. PMID:18394906

Page seeded by OCA on Mon Jul 28 03:23:35 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 {{STRUCTURE_3chp|  PDB=3chp  |  SCENE=  }}
-'''Crystal structure of leukotriene a4 hydrolase in complex with (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acid'''
+===Crystal structure of leukotriene a4 hydrolase in complex with (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acid===
-==Overview==
+<!--
-Leukotriene B(4) (LTB(4)) is a potent pro-inflammatory mediator that has been implicated in the pathogenesis of multiple diseases, including psoriasis, inflammatory bowel disease, multiple sclerosis and asthma. As a method to decrease the level of LTB(4) and possibly identify novel treatments, inhibitors of the LTB(4) biosynthetic enzyme, leukotriene A(4) hydrolase (LTA(4)-h), have been explored. Here we describe the discovery of a potent inhibitor of LTA(4)-h, arylamide of glutamic acid 4f, starting from the corresponding glycinamide 2. Analogs of 4f are then described, focusing on compounds that are both active and stable in whole blood. This effort culminated in the identification of amino alcohol 12a and amino ester 6b which meet these criteria.
+The line below this paragraph, {{ABSTRACT_PUBMED_18394906}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18394906 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_18394906}}
 ==About this Structure==
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 [[Category: Multifunctional enzyme]]
 [[Category: Zinc]]
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