1pqc: Difference between revisions

Revision as of 03:22, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1pqc.png

Template:STRUCTURE 1pqc

HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317

Template:ABSTRACT PUBMED 12819202

About this StructureAbout this Structure

1PQC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands., Farnegardh M, Bonn T, Sun S, Ljunggren J, Ahola H, Wilhelmsson A, Gustafsson JA, Carlquist M, J Biol Chem. 2003 Oct 3;278(40):38821-8. Epub 2003 Jun 20. PMID:12819202

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317'''
+===HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317===
-==Overview==
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-The structures of the liver X receptor LXRbeta (NR1H2) have been determined in complexes with two synthetic ligands, T0901317 and GW3965, to 2.1 and 2.4 A, respectively. Together with its isoform LXRalpha (NR1H3) it regulates target genes involved in metabolism and transport of cholesterol and fatty acids. The two LXRbeta structures reveal a flexible ligand-binding pocket that can adjust to accommodate fundamentally different ligands. The ligand-binding pocket is hydrophobic but with polar or charged residues at the two ends of the cavity. T0901317 takes advantage of this by binding to His-435 close to H12 while GW3965 orients itself with its charged group in the opposite direction. Both ligands induce a fixed "agonist conformation" of helix H12 (also called the AF-2 domain), resulting in a transcriptionally active receptor.
+The line below this paragraph, {{ABSTRACT_PUBMED_12819202}}, adds the Publication Abstract to the page
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 ==About this Structure==
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 [[Category: Wilhelmsson, A.]]
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