2doh: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
[[Image:2doh.jpg|left|200px]]
{{Seed}}
[[Image:2doh.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2doh|  PDB=2doh  |  SCENE=  }}  
{{STRUCTURE_2doh|  PDB=2doh  |  SCENE=  }}  


'''The X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound a to a peptide from the group A streptococcal surface protein PAM'''
===The X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound a to a peptide from the group A streptococcal surface protein PAM===




==Overview==
<!--
The crystal structure of the human Pg-derived angiogenesis inhibitor, angiostatin, complexed to VEK-30, a peptide from the group A streptococcal surface protein, PAM, was determined and refined to 2.3 A resolution. This is the first structure of angiostatin bound to a ligand and provides a model of the interaction between Pg and streptococcal-derived pathogenic proteins. VEK-30 contains a "through-space isostere" for C-terminal lysine, wherein Arg and Glu side chains, separated by one helical turn, bind within the bipolar angiostatin kringle 2 (K2) domain lysine-binding site. VEK-30 also makes several contacts with K2 residues that exist outside of the canonical LBS and are not conserved among the other Pg kringles, thus providing a molecular basis for the selectivity of VEK-30 for K2. The structure also shows that Pg kringle domains undergo significant structural rearrangement relative to one another and reveals dimerization between two molecules of angiostatin and VEK-30 related by crystallographic symmetry. This dimerization, which exists only in the crystal structure, is consistent with the parallel coiled-coil full-length PAM dimer expected from sequence similarities and homology modeling.
The line below this paragraph, {{ABSTRACT_PUBMED_16964966}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16964966 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16964966}}


==Disease==
==Disease==
Line 33: Line 37:
[[Category: Lysine-binding site]]
[[Category: Lysine-binding site]]
[[Category: Plasminogen]]
[[Category: Plasminogen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 00:52:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:03:18 2008''

Revision as of 03:03, 28 July 2008

File:2doh.png

Template:STRUCTURE 2doh

The X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound a to a peptide from the group A streptococcal surface protein PAMThe X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound a to a peptide from the group A streptococcal surface protein PAM

Template:ABSTRACT PUBMED 16964966

DiseaseDisease

Known disease associated with this structure: Conjunctivitis, ligneous OMIM:[173350], Plasminogen Tochigi disease OMIM:[173350], Plasminogen deficiency, types I and II OMIM:[173350], Thrombophilia, dysplasminogenemic OMIM:[173350]

About this StructureAbout this Structure

2DOH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcal surface protein PAM., Cnudde SE, Prorok M, Castellino FJ, Geiger JH, Biochemistry. 2006 Sep 19;45(37):11052-60. PMID:16964966

Page seeded by OCA on Mon Jul 28 03:03:18 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2doh&oldid=677971"