3cig: Difference between revisions

Revision as of 02:49, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:3cig.png

Template:STRUCTURE 3cig

Crystal structure of mouse TLR3 ectodomainCrystal structure of mouse TLR3 ectodomain

Template:ABSTRACT PUBMED 18420935

About this StructureAbout this Structure

3CIG is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis of toll-like receptor 3 signaling with double-stranded RNA., Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM, Davies DR, Science. 2008 Apr 18;320(5874):379-81. PMID:18420935

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal structure of mouse TLR3 ectodomain'''
+===Crystal structure of mouse TLR3 ectodomain===
-==Overview==
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-Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), a molecular signature of most viruses, and triggers inflammatory responses that prevent viral spread. TLR3 ectodomains (ECDs) dimerize on oligonucleotides of at least 40 to 50 base pairs in length, the minimal length required for signal transduction. To establish the molecular basis for ligand binding and signaling, we determined the crystal structure of a complex between two mouse TLR3-ECDs and dsRNA at 3.4 angstrom resolution. Each TLR3-ECD binds dsRNA at two sites located at opposite ends of the TLR3 horseshoe, and an intermolecular contact between the two TLR3-ECD C-terminal domains coordinates and stabilizes the dimer. This juxtaposition could mediate downstream signaling by dimerizing the cytoplasmic Toll interleukin-1 receptor (TIR) domains. The overall shape of the TLR3-ECD does not change upon binding to dsRNA.
+The line below this paragraph, {{ABSTRACT_PUBMED_18420935}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_18420935}}
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 [[Category: Tlr]]
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