2j7n: Difference between revisions

Revision as of 02:49, 28 July 2008

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File:2j7n.png

Template:STRUCTURE 2j7n

STRUCTURE OF THE RNAI POLYMERASE FROM NEUROSPORA CRASSASTRUCTURE OF THE RNAI POLYMERASE FROM NEUROSPORA CRASSA

Template:ABSTRACT PUBMED 17147473

About this StructureAbout this Structure

2J7N is a Single protein structure of sequence from Neurospora crassa. Full crystallographic information is available from OCA.

ReferenceReference

The structure of an RNAi polymerase links RNA silencing and transcription., Salgado PS, Koivunen MR, Makeyev EV, Bamford DH, Stuart DI, Grimes JM, PLoS Biol. 2006 Dec;4(12):e434. PMID:17147473

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+===STRUCTURE OF THE RNAI POLYMERASE FROM NEUROSPORA CRASSA===
-==Overview==
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-RNA silencing refers to a group of RNA-induced gene-silencing mechanisms that developed early in the eukaryotic lineage, probably for defence against pathogens and regulation of gene expression. In plants, protozoa, fungi, and nematodes, but apparently not insects and vertebrates, it involves a cell-encoded RNA-dependent RNA polymerase (cRdRP) that produces double-stranded RNA triggers from aberrant single-stranded RNA. We report the 2.3-A resolution crystal structure of QDE-1, a cRdRP from Neurospora crassa, and find that it forms a relatively compact dimeric molecule, each subunit of which comprises several domains with, at its core, a catalytic apparatus and protein fold strikingly similar to the catalytic core of the DNA-dependent RNA polymerases responsible for transcription. This evolutionary link between the two enzyme types suggests that aspects of RNA silencing in some organisms may recapitulate transcription/replication pathways functioning in the ancient RNA-based world.
+The line below this paragraph, {{ABSTRACT_PUBMED_17147473}}, adds the Publication Abstract to the page
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 [[Category: Rna-directed rna polymerase]]
 [[Category: Rnai response]]
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