|
|
| Line 1: |
Line 1: |
| [[Image:1vzv.gif|left|200px]] | | {{Seed}} |
| | [[Image:1vzv.png|left|200px]] |
|
| |
|
| <!-- | | <!-- |
| Line 9: |
Line 10: |
| {{STRUCTURE_1vzv| PDB=1vzv | SCENE= }} | | {{STRUCTURE_1vzv| PDB=1vzv | SCENE= }} |
|
| |
|
| '''STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE'''
| | ===STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE=== |
|
| |
|
|
| |
|
| ==Overview==
| | <!-- |
| Varicella-zoster virus (VZV), an alpha-herpes virus, is the causative agent of chickenpox, shingles, and postherpetic neuralgia. The three-dimensional crystal structure of the serine protease from VZV has been determined at 3.0-A resolution. The VZV protease is essential for the life cycle of the virus and is a potential target for therapeutic intervention. The structure reveals an overall fold that is similar to that recently reported for the serine protease from cytomegalovirus (CMV), a herpes virus of the beta subfamily. The VZV protease structure provides further evidence to support the finding that herpes virus proteases have a fold and active site distinct from other serine proteases. The VZV protease catalytic triad consists of a serine and two histidines. The distal histidine is proposed to properly orient the proximal histidine. The identification of an alpha-helical segment in the VZV protease that was mostly disordered in the CMV protease provides a better definition of the postulated active site cavity and reveals an elastase-like S' region. Structural differences between the VZV and CMV proteases also suggest potential differences in their oligomerization states.
| | The line below this paragraph, {{ABSTRACT_PUBMED_9096314}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 9096314 is the PubMed ID number. |
| | --> |
| | {{ABSTRACT_PUBMED_9096314}} |
|
| |
|
| ==About this Structure== | | ==About this Structure== |
| Line 33: |
Line 37: |
| [[Category: Varicella-zoster virus]] | | [[Category: Varicella-zoster virus]] |
| [[Category: Viral protease]] | | [[Category: Viral protease]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:58:03 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:11:47 2008'' |