2dxs: Difference between revisions

Revision as of 01:42, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2dxs.png

Template:STRUCTURE 2dxs

Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitorCrystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor

Template:ABSTRACT PUBMED 17125247

About this StructureAbout this Structure

2DXS is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

ReferenceReference

Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors., Ikegashira K, Oka T, Hirashima S, Noji S, Yamanaka H, Hara Y, Adachi T, Tsuruha J, Doi S, Hase Y, Noguchi T, Ando I, Ogura N, Ikeda S, Hashimoto H, J Med Chem. 2006 Nov 30;49(24):6950-3. PMID:17125247

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor'''
+===Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor===
-==Overview==
+<!--
-We report a new series of hepatitis C virus NS5B RNA polymerase inhibitors containing a conformationally constrained tetracyclic scaffold. SAR studies led to the identification of 6,7-dihydro-5H-benzo[5,6][1,4]diazepino[7,1-a]indoles (19 and 20) bearing a basic pendent group with high biochemical and cellular potencies. These compounds displayed a very small shift in cellular potency when the replicon assay was performed in the presence of human serum albumin.
+The line below this paragraph, {{ABSTRACT_PUBMED_17125247}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17125247 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_17125247}}
 ==About this Structure==
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 [[Category: Ns5b]]
 [[Category: Rna polymerase]]
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