2e1w: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:2e1w.gif|left|200px]]
+{{Seed}}
+[[Image:2e1w.png|left|200px]]
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 {{STRUCTURE_2e1w|  PDB=2e1w  |  SCENE=  }}
-'''Crystal structure of adenosine deaminase complexed with potent inhibitors'''
+===Crystal structure of adenosine deaminase complexed with potent inhibitors===
-==Overview==
+<!--
-We disclose optimization efforts based on the novel non-nucleoside adenosine deaminase (ADA) inhibitor, 4 (K(i) = 680 nM). Structure-based drug design utilizing the crystal structure of the 4/ADA complex led to discovery of 5 (K(i) = 11 nM, BA = 30% in rats). Furthermore, from metabolic considerations, we discovered two inhibitors with improved oral bioavailability [6 (K(i) = 13 nM, BA = 44%) and 7 (K(i) = 9.8 nM, BA = 42%)]. 6 demonstrated in vivo efficacy in models of inflammation and lymphoma.
+The line below this paragraph, {{ABSTRACT_PUBMED_15139750}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15139750 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15139750}}
 ==About this Structure==
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 [[Category: Beta barrel]]
 [[Category: Zinc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 01:46:08 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:09:24 2008''