2qpl: Difference between revisions

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-[[Image:2qpl.jpg|left|200px]]
+{{Seed}}
+[[Image:2qpl.png|left|200px]]
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 {{STRUCTURE_2qpl|  PDB=2qpl  |  SCENE=  }}
-'''Crystal structure of calf spleen purine nucleoside phosphorylase complexed to a novel purine analogue'''
+===Crystal structure of calf spleen purine nucleoside phosphorylase complexed to a novel purine analogue===
-==Overview==
+<!--
-The combined use of a rapid virtual screen of a small fragment library together with a single point enzyme assay has been used for the discovery of novel PNP inhibitors. The availability of readily soakable crystals of bovine PNP has allowed the approach to be experimentally validated by determining the crystal structure of one of the inhibitor-PNP complexes. Comparison of the experimentally determined binding mode with that predicted by the virtual screening shows them to be similar. This represents a starting point for the growth of the ligand into a higher affinity inhibitor.
+The line below this paragraph, {{ABSTRACT_PUBMED_17927987}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17927987 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17927987}}
 ==About this Structure==
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 [[Category: Purine nucleoside phosphorylase]]
 [[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 15:22:26 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:43:38 2008''