3bcj: Difference between revisions

Revision as of 00:41, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:3bcj.png

Template:STRUCTURE 3bcj

Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 ACrystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A

Template:ABSTRACT PUBMED 18284183

About this StructureAbout this Structure

3BCJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Unusual Binding Mode of the 2S4R Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2S4S) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 A Resolution: Implications for the Inhibition Mechanism., Zhao HT, Hazemann I, Mitschler A, Carbone V, Joachimiak A, Ginell S, Podjarny A, El-Kabbani O, J Med Chem. 2008 Mar 13;51(5):1478-1481. Epub 2008 Feb 20. PMID:18284183

Page seeded by OCA on Mon Jul 28 00:41:57 2008

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OCA

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-'''Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A'''
+===Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A===
-==Overview==
+<!--
-The structure of human aldose reductase in complex with the 2 S4 R stereoisomer of the potent inhibitor Fidarestat ((2 S,4 S)-6-fluoro-2',5'-dioxospiro-[chroman-4,4'-imidazoline]-2-carboxamide) was determined at 15 K and a resolution of 0.78 A. The structure of the complex provides experimental evidence for the inhibition mechanism in which Fidarestat is initially bound neutral and then becomes negatively charged by donating the proton at the 1'-position nitrogen of the cyclic imide ring to the N2 atom of the catalytic His110.
+The line below this paragraph, {{ABSTRACT_PUBMED_18284183}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18284183 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_18284183}}
 ==About this Structure==
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 [[Category: Polyl pathway]]
 [[Category: Polymorphism]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:41:57 2008''