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| [[Image:2eig.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2eig| PDB=2eig | SCENE= }} | | {{STRUCTURE_2eig| PDB=2eig | SCENE= }} |
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| '''Lotus tetragonolobus seed lectin (Isoform)'''
| | ===Lotus tetragonolobus seed lectin (Isoform)=== |
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| ==Overview==
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| Lotus tetragonolobus lectin (LTA) is a fucose-specific legume lectin. Although several studies report a diverse combination of biological activities for LTA, little is known about the mechanisms involved in l-fucosyl oligosaccharide recognition. The crystal structure of LTA at 2.0A resolution reveals a different legume lectin tetramer. Its structure consists of a homotetramer composed of two back-to-back GS4-like dimers arranged in a new mode, resulting in a novel tetramer. The LTA N-linked carbohydrate at Asn4 and the unusual LTA dimer-dimer interaction are related to its particular mode of tetramerization. In addition, we used small angle X-ray scattering to investigate the quaternary structure of LTA in solution and to compare it to the crystalline structure. Although the crystal structure of LTA has revealed a conserved metal-binding site, its l-fucose-binding site presents some punctual differences. Our investigation of the new tetramer of LTA and its fucose-binding site is essential for further studies related to cross-linking between LTA and complex divalent l-fucosyl carbohydrates.
| | The line below this paragraph, {{ABSTRACT_PUBMED_18068379}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 18068379 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_18068379}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: N-acetyl-d-glucosamine]] | | [[Category: N-acetyl-d-glucosamine]] |
| [[Category: Sugar binding protein]] | | [[Category: Sugar binding protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 02:35:54 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:40:35 2008'' |