1muj: Difference between revisions

Revision as of 00:34, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1muj.png

Template:STRUCTURE 1muj

Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptideCrystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide

Template:ABSTRACT PUBMED 12589760

About this StructureAbout this Structure

1MUJ is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif., Zhu Y, Rudensky AY, Corper AL, Teyton L, Wilson IA, J Mol Biol. 2003 Feb 28;326(4):1157-74. PMID:12589760

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide'''
+===Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide===
-==Overview==
+<!--
-Association between the class II major histocompatibility complex (MHC) and the class II invariant chain-associated peptide (CLIP) occurs naturally as an intermediate step in the MHC class II processing pathway. Here, we report the crystal structure of the murine class II MHC molecule I-A(b) in complex with human CLIP at 2.15A resolution. The structure of I-A(b) accounts, via the peptide-binding groove's unique physicochemistry, for the distinct peptide repertoire bound by this allele. CLIP adopts a similar conformation to peptides bound by other I-A alleles, reinforcing the notion that CLIP is presented as a conventional peptide antigen. When compared to the related HLA-DR3/CLIP complex structure, the CLIP peptide displays a slightly different conformation and distinct interaction pattern with residues in I-A(b). In addition, after examining the published sequences of peptides presented by I-A(b), we discuss the possibility of predicting peptide alignment in the I-A(b) binding groove using a simple scoring matrix.
+The line below this paragraph, {{ABSTRACT_PUBMED_12589760}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12589760 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_12589760}}
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 [[Category: I-ab]]
 [[Category: Peptide]]
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