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| {{STRUCTURE_1za4| PDB=1za4 | SCENE= }} | | {{STRUCTURE_1za4| PDB=1za4 | SCENE= }} |
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| '''Crystal Structure of the Thrombospondin-1 N-terminal Domain in Complex with Arixtra'''
| | ===Crystal Structure of the Thrombospondin-1 N-terminal Domain in Complex with Arixtra=== |
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| ==Overview==
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| The N-terminal domain of thrombospondin-1 (TSPN-1) mediates the protein's interaction with (1) glycosaminoglycans, calreticulin, and integrins during cellular adhesion, (2) low-density lipoprotein receptor-related protein during uptake and clearance, and (3) fibrinogen during platelet aggregation. The crystal structure of TSPN-1 to 1.8 A resolution is a beta sandwich with 13 antiparallel beta strands and 1 irregular strand-like segment. Unique structural features of the N- and C-terminal regions, and the disulfide bond location, distinguish TSPN-1 from the laminin G domain and other concanavalin A-like lectins/glucanases superfamily members. The crystal structure of the complex of TSPN-1 with heparin indicates that residues R29, R42, and R77 in an extensive positively charged patch at the bottom of the domain specifically associate with the sulfate groups of heparin. The TSPN-1 structure and identified adjacent linker region provide a structural framework for the analysis of the TSPN domain of various molecules, including TSPs, NELLs, many collagens, TSPEAR, and kielin. | | The line below this paragraph, {{ABSTRACT_PUBMED_16407063}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16407063 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16407063}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Ntsp-1]] | | [[Category: Ntsp-1]] |
| [[Category: Tsp-1]] | | [[Category: Tsp-1]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:22:33 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:10:42 2008'' |