2ghl: Difference between revisions

Revision as of 00:03, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2ghl.png

Template:STRUCTURE 2ghl

Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743

Template:ABSTRACT PUBMED 16632356

About this StructureAbout this Structure

2GHL is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1., Brugel TA, Maier JA, Clark MP, Sabat M, Golebiowski A, Bookland RG, Laufersweiler MJ, Laughlin SK, Vanrens JC, De B, Hsieh LC, Mekel MJ, Janusz MJ, Bioorg Med Chem Lett. 2006 Jul 1;16(13):3510-3. Epub 2006 May 2. PMID:16632356

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OCA

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-'''Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743'''
+===Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743===
-==Overview==
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-A new class of tumor necrosis factor alpha (TNF-alpha) synthesis inhibitors based on an N-2,4-pyrimidine-N-phenyl-N'-phenyl urea scaffold is described. Many of these compounds showed low-nanomolar activity against lipopolysaccharide stimulated TNF-alpha production. X-ray co-crystallization studies with mutated p38alpha showed that these trisubstituted ureas interact with the ATP-binding pocket in a pseudo-bicyclic conformation brought about by the presence of an intramolecular hydrogen bonding interaction.
+The line below this paragraph, {{ABSTRACT_PUBMED_16632356}}, adds the Publication Abstract to the page
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 ==About this Structure==
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 [[Category: Map kinase p38]]
 [[Category: P38]]
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