1rs0: Difference between revisions

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[[Image:1rs0.gif|left|200px]]
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{{STRUCTURE_1rs0|  PDB=1rs0  |  SCENE=  }}  
{{STRUCTURE_1rs0|  PDB=1rs0  |  SCENE=  }}  


'''Crystal Structure Analysis of the Bb segment of Factor B complexed with Di-isopropyl-phosphate (DIP)'''
===Crystal Structure Analysis of the Bb segment of Factor B complexed with Di-isopropyl-phosphate (DIP)===




==Overview==
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The C-terminal fragment, Bb, of factor B combines with C3b to form the pivotal C3-convertase, C3bBb, of alternative complement pathway. Bb consists of a von Willebrand factor type A (vWFA) domain that is structurally similar to the I domains of integrins and a serine protease (SP) domain that is in inactive conformation. The structure of the C3bBb complex would be important in deciphering the activation mechanism of the SP domain. However, C3bBb is labile and not amenable to X-ray diffraction studies. We engineered a disulfide bond in the vWFA domain of Bb homologous to that shown to lock I domains in active conformation. The crystal structures of Bb(C428-C435) and its inhibitor complexes reveal that the adoption of the "active" conformation by the vWFA domain is not sufficient to activate the C3-convertase catalytic apparatus and also provide insights into the possible mode of C3-convertase activation.
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==Disease==
==Disease==
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[[Category: Factor b]]
[[Category: Factor b]]
[[Category: Factor bb-dip complex]]
[[Category: Factor bb-dip complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:50:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:58:19 2008''

Revision as of 23:58, 27 July 2008

File:1rs0.png

Template:STRUCTURE 1rs0

Crystal Structure Analysis of the Bb segment of Factor B complexed with Di-isopropyl-phosphate (DIP)Crystal Structure Analysis of the Bb segment of Factor B complexed with Di-isopropyl-phosphate (DIP)

Template:ABSTRACT PUBMED 15068800

DiseaseDisease

Known disease associated with this structure: Macular degeneration, age-related, reduced risk of OMIM:[138470]

About this StructureAbout this Structure

1RS0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase., Ponnuraj K, Xu Y, Macon K, Moore D, Volanakis JE, Narayana SV, Mol Cell. 2004 Apr 9;14(1):17-28. PMID:15068800

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