1q1j: Difference between revisions

Revision as of 23:44, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1q1j.png

Template:STRUCTURE 1q1j

Crystal Structure Analysis of anti-HIV-1 Fab 447-52D in complex with V3 peptideCrystal Structure Analysis of anti-HIV-1 Fab 447-52D in complex with V3 peptide

Template:ABSTRACT PUBMED 14962380

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D., Stanfield RL, Gorny MK, Williams C, Zolla-Pazner S, Wilson IA, Structure. 2004 Feb;12(2):193-204. PMID:14962380

Page seeded by OCA on Sun Jul 27 23:44:18 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1q1j.gif|left|200px]]
+{{Seed}}
+[[Image:1q1j.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1q1j|  PDB=1q1j  |  SCENE=  }}
-'''Crystal Structure Analysis of anti-HIV-1 Fab 447-52D in complex with V3 peptide'''
+===Crystal Structure Analysis of anti-HIV-1 Fab 447-52D in complex with V3 peptide===
-==Overview==
+<!--
--52D is a human monoclonal antibody isolated from a heterohybridoma derived from an HIV-1-infected individual. This antibody recognizes the hypervariable gp120 V3 loop, and neutralizes both X4 and R5 primary isolates, making it one of the most effective anti-V3 antibodies characterized to date. The crystal structure of the 447-52D Fab in complex with a 16-mer V3 peptide at 2.5 A resolution reveals that the peptide beta hairpin forms a three-stranded mixed beta sheet with complementarity determining region (CDR) H3, with most of the V3 side chains exposed to solvent. Sequence specificity is conferred through interaction of the type-II turn (residues GPGR) at the apex of the V3 hairpin with the base of CDR H3. This novel mode of peptide-antibody recognition enables the antibody to bind to many different V3 sequences where only the GPxR core epitope is absolutely required.
+The line below this paragraph, {{ABSTRACT_PUBMED_14962380}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14962380 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14962380}}
 ==About this Structure==
@@ Line 29: / Line 33: @@
 [[Category: Hiv-1]]
 [[Category: V3 loop]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:45:09 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:44:18 2008''